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Clin Chim Acta. 2017 Apr;467:48-50. doi: 10.1016/j.cca.2016.05.031. Epub 2016 Jun 1.

Development of a Certified Reference Material for myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA).

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European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel, Belgium.
Protein Reference Unit and Immunopathology Department, St Georges' Hospital, London, United Kingdom.
Department of Clinical Sciences and Community Health & Istituto Auxologico Italiano, Milan, Italy.


A serum Certified Reference Material (CRM) for supporting reliable autoimmune diagnostics was recently released by the Institute for Reference Materials and Measurements (IRMM) of the Joint Research Centre of the European Commission. It was produced in collaboration with a Working Group on the Harmonisation of Autoimmune Tests of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC WG-HAT). This material is aimed at facilitating the standardisation of measurements of anti-myeloperoxidase immunoglobulin G antibodies. The CRM could be used as a common calibrant by clinicians and manufacturers thereby significantly improving the comparability of results from commercial immunoassays used for IgG anti-MPO measurements. This paper provides information on the new CRM and its intended use.


Certified reference material; Myeloperoxidase; Standardisation; Vasculitis

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