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Arch Biochem Biophys. 2016 Dec 1;611:79-85. doi: 10.1016/j.abb.2016.05.022. Epub 2016 Jun 1.

Zinc and diabetes.

Author information

1
Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, London, W120NN, UK.
2
Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, London, W120NN, UK. Electronic address: g.rutter@imperial.ac.uk.

Abstract

Zn2+ ions are essential for the normal processing and storage of insulin and altered pancreatic insulin content is associated with all forms of diabetes mellitus. Work of the past decade has identified variants in the human SLC30A8 gene, encoding the zinc transporter ZnT8 which is expressed highly selectively on the secretory granule of pancreatic islet β and α cells, as affecting the risk of Type 2 Diabetes. Here, we review the regulation and roles of Zn2+ ions in islet cells, the mechanisms through which SLC30A8 variants might affect glucose homeostasis and diabetes risk, and the novel technologies including recombinant targeted zinc probes and knockout mice which have been developed to explore these questions.

KEYWORDS:

Beta cell; Diabetes; Insulin; Mouse; Zinc; Zinc probe

PMID:
27262257
DOI:
10.1016/j.abb.2016.05.022
[Indexed for MEDLINE]
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