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Am J Med. 2016 Oct;129(10):1126-30. doi: 10.1016/j.amjmed.2016.04.034. Epub 2016 May 31.

The Clinical Spectrum of Zika Virus in Returning Travelers.

Author information

1
Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Israel.
2
The Central Virology Laboratory, Ministry of Health at the Sheba Medical Center, Tel Hashomer, Israel.
3
The Sackler School of Medicine, Tel Aviv University, Israel; The Pediatric Infectious Disease Unit, Meir Medical Center, Kfar Saba, Israel.
4
Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Israel. Electronic address: elischwa@post.tau.ac.il.

Abstract

INTRODUCTION:

The clinical spectrum of Zika virus had, to date, been described in small series from endemic/epidemic countries and is not well established.

METHODS:

We describe the clinical manifestations of laboratory-proven Zika virus infection in Israeli travelers during December 2015-February 2016, and review all published cases of travel-related Zika virus.

RESULTS:

During the study period, 8 returning Israeli travelers were diagnosed with Zika virus infection. In addition, 41 published cases were included, mostly from Latin America to Europe and North America. Overall, 65.3% were diagnosed by polymerase chain reaction. Rash was the most frequent symptom, present in 95.7% of cases, followed by fever and arthralgia. Conjunctivitis was present in 53.1%; however, only 40.3% presented with a triad of conjunctivitis, fever, and rash. Less frequent symptoms included dysgeusia and nightmares, which, together with arthralgia, persisted for several weeks in some travelers.

CONCLUSIONS:

Zika virus clinical picture in travelers is diverse. Prolonged symptoms may occur.

KEYWORDS:

Arboviruses; Israel; Travel; Zika virus

Comment in

PMID:
27260832
DOI:
10.1016/j.amjmed.2016.04.034
[Indexed for MEDLINE]

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