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Neurosci Lett. 1989 May 8;99(3):257-62.

Induction of neurite outgrowth from chick embryonic ganglia explants by activators of protein kinase C.

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  • 1Department of Biology, Seton Hall University, South Orange, NJ 07079.

Abstract

Neurite outgrowth from chick embryonic sensory ganglia explants was induced by activators of protein kinase C and other compounds known to stimulate the hydrolysis of inositol phospholipids. The addition of diacylglycerols, phospholipase C and muscarine chloride to a defined growth medium promoted the outgrowth of dense neurites from ganglia explants which were morphologically distinct from those induced by the phorbol ester TPA. Moreover, these neurite-promoting agents did not enhance non-neuronal cell proliferation and were ineffective in the absence of insulin and/or progesterone.

PMID:
2725953
[PubMed - indexed for MEDLINE]
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