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Cell Biochem Biophys. 2015 Dec;73(3):681-6. doi: 10.1007/s12013-015-0694-5.

Curcumin Promotes Cell Cycle Arrest and Inhibits Survival of Human Renal Cancer Cells by Negative Modulation of the PI3K/AKT Signaling Pathway.

Author information

1
Department of Urology Surgery, The Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 195 of Tongbai Road, Zhengzhou, 450007, China. drzhanghao01@163.com.
2
Department of Urology Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
3
Department of Anesthesiology, The Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450007, China.
4
Department of Urology Surgery, The Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 195 of Tongbai Road, Zhengzhou, 450007, China.

Abstract

Curcumin possesses anti-cancer effects. In the current study, we tested the effect of curcumin on cell proliferation, viability, apoptosis, cell cycle phases, and activation of the PI3K/Akt pathway in the renal cell carcinoma (RCC) cell line RCC-949. We observed that cell proliferation and viability were markedly inhibited by curcumin, while cell apoptosis was promoted. The latter effect was associated with increased expression of Bcl-2 and diminished expression of Bax (both: mRNA and protein). The cells treated with curcumin increasingly went into cell cycle arrest, which was likely mediated by diminished expression of cyclin B1, as seen in curcumin-treated cells. In addition, curcumin decreased activation of the PI3K/AKT signaling pathway. In conclusion, our results demonstrate that curcumin exerts anti-cancer effects by negative modulation of the PI3K/AKT signaling pathway and may represent a promising new drug to treat RCC.

KEYWORDS:

AKT; Cell apoptosis; Cell cycle arrest; Curcumin; Human renal cell carcinoma; PI3K

PMID:
27259310
DOI:
10.1007/s12013-015-0694-5
[Indexed for MEDLINE]

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