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Mol Cell. 2016 Jun 2;62(5):681-94. doi: 10.1016/j.molcel.2016.05.004.

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.

Author information

1
Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA. Electronic address: asoshnev@rockefeller.edu.
2
Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.
3
Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA. Electronic address: alliscd@rockefeller.edu.

Abstract

Information encoded in DNA is interpreted, modified, and propagated as chromatin. The diversity of inputs encountered by eukaryotic genomes demands a matching capacity for transcriptional outcomes provided by the combinatorial and dynamic nature of epigenetic processes. Advances in genome editing, visualization technology, and genome-wide analyses have revealed unprecedented complexity of chromatin pathways, offering explanations to long-standing questions and presenting new challenges. Here, we review recent findings, exemplified by the emerging understanding of crossregulatory interactions within chromatin, and emphasize the pathologic outcomes of epigenetic misregulation in cancer.

PMID:
27259201
PMCID:
PMC4898265
DOI:
10.1016/j.molcel.2016.05.004
[Indexed for MEDLINE]
Free PMC Article

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