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Cell. 2016 Jun 2;165(6):1316-1318. doi: 10.1016/j.cell.2016.05.060.

A TOGgle for Tension at Kinetochores.

Author information

1
Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, CA 92093, USA; Ludwig Institute for Cancer Research, San Diego, CA 92093, USA.
2
Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, CA 92093, USA; Ludwig Institute for Cancer Research, San Diego, CA 92093, USA. Electronic address: abdesai@ucsd.edu.

Abstract

Differential stability of kinetochore-microtubule attachments at low versus high tension is critical for accurate chromosome segregation. Miller et al. find that a TOG domain microtubule-binding protein imparts intrinsic tension selectivity to kinetochore-microtubule attachments.

PMID:
27259144
PMCID:
PMC5572793
DOI:
10.1016/j.cell.2016.05.060
[Indexed for MEDLINE]
Free PMC Article

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