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Autoimmunity. 2016 Sep;49(6):357-365. Epub 2016 Jun 3.

Recent advances of exosomes in immune modulation and autoimmune diseases.

Tan L1,2, Wu H2, Liu Y2, Zhao M2, Li D3, Lu Q2.

Author information

1
a Department of Dermatology , Third Xiangya Hospital, Central South University , Changsha , P.R. China.
2
b Department of Dermatology , Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics , Changsha , P.R. China , and.
3
c Department of Pathology , Second Xiangya Hospital, Central South University , Changsha , P.R. China.

Abstract

Exosomes are small membrane-bound vesicles (30-100 nm) that are secreted by different types of cells and they have been well documented to resemble saucers or flattened spheres under the electron microscope. Recently, evidence indicates that exosomes play important roles in the immune modulation and are associated with the immune pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA), Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). In this review, we will summarize current research advances of exosomes in immunoregulation, pathogenesis, diagnosis and therapeutics of autoimmune diseases.

KEYWORDS:

Exosome; Sjogren’s syndrome; microRNA; rheumatoid arthritis; systemic lupus erythematosus

PMID:
27259064
DOI:
10.1080/08916934.2016.1191477
[Indexed for MEDLINE]

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