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Curr Opin Crit Care. 2016 Aug;22(4):370-8. doi: 10.1097/MCC.0000000000000318.

Update on perioperative acute kidney injury.

Author information

1
Division of Anesthesiology, Pain, and Intensive Care, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Abstract

PURPOSE OF REVIEW:

In this review, we discuss the latest updates on perioperative acute kidney injury (AKI) and the specific considerations that are relevant to different surgeries and patient populations.

RECENT FINDINGS:

AKI diagnosis is constantly evolving. New biomarkers detect AKI early and shed a light on the possible cause of AKI. Hypotension, even for a short duration, is associated with perioperative AKI. The debate on the deleterious effects of chloride-rich solutions is still far from conclusion. Remote ischemic preconditioning is showing promising results in the possible prevention of perioperative AKI. No definite data show a beneficiary effect of statins, fenoldepam, or sodium bicarbonate in preventing AKI.

SUMMARY:

Perioperative AKI is prevalent and associated with significant morbidity and mortality. Considering the lack of effective preventive or therapeutic interventions, this review focuses on perioperative AKI: measures for early diagnosis, defining risks and possible mechanisms, and summarizing current knowledge for intraoperative fluid and hemodynamic management to reduce risk of AKI.

PMID:
27258664
DOI:
10.1097/MCC.0000000000000318
[Indexed for MEDLINE]

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