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Environ Int. 2016 Sep;94:189-195. doi: 10.1016/j.envint.2016.05.018. Epub 2016 May 31.

Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status.

Author information

1
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, China.
2
Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
3
Department of Environmental & Occupational Health, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
4
Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
5
Department of Epidemiology and Biostatistics, School of Public Health, State University of New York, Albany, NY 12144-3445, USA.
6
Institute of Occupational Medicine and Industrial Hygiene and Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
7
Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan. Electronic address: leolee@ntu.edu.tw.
8
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: donggh5@mail.sysu.edu.cn.

Abstract

Polyfluoroalkyl substances (PFASs) are a group of common chemicals that ubiquitously exist in wildlife and humans. However, few studies have researched the effect of PFASs on reproductive hormones in adolescents. To provide information in this regard, we recruited 225 Taiwanese adolescents aged 13-15years from 2009 to 2010 to investigate the relationship between serum PFASs (PFOS, PFOA, PFBS, PFDA, PFDoA, PFHxA, PFHxS, PFNA and PFTA) and reproductive hormone concentrations using a cross-sectional study design. Results showed PFOS and PFTA levels were highest among the PFASs, with a median concentrations of 29.9 (interquartile range: 13.0-43.8) ng/mL and 6.0 (0.6-25.9) ng/mL in males, and a median concentrations of 28.8 (14.8-42.6) ng/mL and 4.5 (0.3-18.4) ng/mL in females. After adjustment for confounding factors, nonsignificant associations between PFASs and reproductive hormone were found except for PFNA with ln(estradiol) (β=0.2060, 95%CI: 0.0016, 0.4105). When stratified by sex, more significant associations were found in males than in females. Among males, PFASs were negatively associated with ln(testosterone) level for PFOS (β=-0.0029, 95%CI: -0.0055, -0.0003), PFDA (β=-0.2565, 95%CI: -0.4135, -0.0994), PFHxA (β=-0.3095, 95%CI: -0.5942, -0.0248), and PFNA (β=-0.4233, 95%CI: -0.6998, -0.1467). Furthermore, male participant ln(estradiol) levels were positively associated with PFOA (β=0.0921, 95%CI: 0.0186, 0.1656), and PFHxS (β=0.0462, 95%CI: 0.0020, 0.0905). Among females, a significant relationship was found only for PFDoA with ln(testosterone) (β=-0.0119, 95%CI: -0.0227, -0.0010). In conclusion, this study showed higher levels of PFASs coincide with lower testosterone and higher estradiol levels, and more significant associations of PFASs with reproductive hormone were found in males than in females.

KEYWORDS:

Adolescents; Estradiol; Perfluoroalkyl substances; Sex; Testosterone

PMID:
27258660
DOI:
10.1016/j.envint.2016.05.018
[Indexed for MEDLINE]

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