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PLoS One. 2016 Jun 3;11(6):e0154173. doi: 10.1371/journal.pone.0154173. eCollection 2016.

Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease.

Author information

1
Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
2
Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
3
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
4
Department of Clinical Trial and Clinical Epidemiology, University of Tsukuba, Ibaraki, Japan.
5
Department of Clinical Oncology, Ibaraki Prefectural Central Hospital, Ibaraki, Japan.
6
Ibaraki Clinical Education and Training Center, University of Tsukuba Hospital, Ibaraki, Japan.
7
Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, Japan.
8
Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), University of Tsukuba, Ibaraki, Japan.

Abstract

Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera. In retrospective univariate and multivariate analyses of allo-HSCT patients (n = 71) at a single center, cumulative incidences of all grade (grade I-IV) and sgrade II-IV aGVHD in patients with high maximal serum levels of sDNAM-1 (≥30 pM) in the 7 days before allo-HSCT were significantly higher than those in patients with low maximal serum levels of sDNAM-1 (<30 pM) in the same period. However, sDNAM-1 was not associated with other known allo-HSCT complications. Our data suggest that sDNAM-1 is potentially a unique candidate as a predictive biomarker for the development of aGVHD.

PMID:
27257974
PMCID:
PMC4892670
DOI:
10.1371/journal.pone.0154173
[Indexed for MEDLINE]
Free PMC Article

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