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Biomol Ther (Seoul). 2016 Nov 1;24(6):616-622. doi: 10.4062/biomolther.2016.022.

Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress.

Author information

1
School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
2
College of Medicine, Soonchunhyang University, Cheonan 31140, Republic of Korea.
3
Radiation Biotechnology Research Division, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea.
4
Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon 34057, Republic of Korea.
5
Department of Radiation Biotechnology and Applied Radioisotope, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.

Abstract

Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.

KEYWORDS:

Baicalein; HaCaT cells; Oxidative stress; Reactive oxygen species; Ultraviolet B

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