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Nat Rev Neurosci. 2016 Aug;17(8):524-32. doi: 10.1038/nrn.2016.57. Epub 2016 Jun 3.

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression.

Author information

1
Departments of Neuroscience, Psychiatry and Psychology, Department of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Abstract

The dopamine system is unique among the brain's modulatory systems in that it has discrete projections to specific brain regions involved in motor behaviour, cognition and emotion. Dopamine neurons exhibit several activity patterns - including tonic and phasic firing - that are determined by a combination of endogenous pacemaker conductances and regulation by multiple afferent systems. Emerging evidence suggests that disruptions in these regulatory systems may underlie the pathophysiology of several psychiatric disorders, including schizophrenia and depression.

PMID:
27256556
PMCID:
PMC5166560
DOI:
10.1038/nrn.2016.57
[Indexed for MEDLINE]
Free PMC Article

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