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Nat Rev Drug Discov. 2016 Sep;15(9):639-660. doi: 10.1038/nrd.2016.75. Epub 2016 Jun 3.

Targeting adipose tissue in the treatment of obesity-associated diabetes.

Author information

1
Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center.
2
Division of Endocrinology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Abstract

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.

PMID:
27256476
DOI:
10.1038/nrd.2016.75
[Indexed for MEDLINE]

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