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Am J Med Genet B Neuropsychiatr Genet. 2016 Dec;171(8):1013-1022. doi: 10.1002/ajmg.b.32464. Epub 2016 Jun 3.

Whole-exome sequencing implicates DGKH as a risk gene for panic disorder in the Faroese population.

Author information

1
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
2
Department of Biomedicine and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
3
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
4
Genetic Biobank of the Faroe Islands, Torshavn, Faroe Islands.
5
BGI-Shenzhen, Shenzhen, China.
6
Centre of Psychiatry Amager, Copenhagen University Hospital, Copenhagen, Denmark.
7
Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.

Abstract

The demographic history of the isolated population of the Faroe Islands may have induced enrichment of variants rarely seen in outbred European populations, including enrichment of risk variants for panic disorder (PD). PD is a common mental disorder, characterized by recurring and unprovoked panic attacks, and genetic factors have been estimated to explain around 40% of the risk. In this study the potential enrichment of PD risk variants was explored based on whole-exome sequencing of 54 patients with PD and 211 control individuals from the Faroese population. No genome-wide significant associations were found, however several single variants and genes showed strong association with PD, where DGKH was found to be the strongest PD associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. Additionally, we found an enrichment of PD risk variants in the Faroese population; variants with otherwise low frequency in more outbreed European populations.

KEYWORDS:

DGKH; isolated population; panic disorder; whole-exome sequencing

PMID:
27255576
DOI:
10.1002/ajmg.b.32464
[Indexed for MEDLINE]

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