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J Evid Based Complementary Altern Med. 2016 Oct;21(4):NP91-7. doi: 10.1177/2156587216650775. Epub 2016 Jun 2.

Efficacy of the Hydroalcoholic Extract of Tribulus terrestris on the Serum Glucose and Lipid Profile of Women With Diabetes Mellitus: A Double-Blind Randomized Placebo-Controlled Clinical Trial.

Author information

1
Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
2
Community Based Psychiatric Care Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran jokarhs@yahoo.com.
3
Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4
Department of Traditional Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
5
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

AIM:

Considering traditional use of Tribulus terrestris in diabetes and proven antihyperglycemic and antihyperlipidemic effects of T terrestris in animal studies, we aimed to evaluate the efficacy of the hydroalcoholic extract of T terrestris on the serum glucose and lipid profile of women with non-insulin-dependent diabetes mellitus.

METHODS:

Ninety-eight women with diabetes mellitus type 2 were randomly allocated to receive the T terrestris (1000 mg/d) or placebo for 3 months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin, and lipid profile.

RESULTS:

Tribulus terrestris showed a significant blood glucose-lowering effect in diabetic women compared to placebo (P < .05). Also, the total cholesterol and low-density lipoprotein of T terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels.

CONCLUSIONS:

The study showed preliminary promising hypoglycemic effect of T terrestris in women with diabetes mellitus type 2.

KEYWORDS:

Tribulus terrestris; diabetes mellitus; herbal medicine; traditional medicine

PMID:
27255456
DOI:
10.1177/2156587216650775
[Indexed for MEDLINE]

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