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Trends Mol Med. 2016 Jul;22(7):529-30. doi: 10.1016/j.molmed.2016.05.009. Epub 2016 May 30.

Engineering Paper-Based Sensors for Zika Virus.

Author information

  • 1Sandia National Laboratories, Biotechnology and Bioengineering Department, Livermore, CA 94551, USA. Electronic address: rmeaghe@sandia.gov.
  • 2Sandia National Laboratories, Biotechnology and Bioengineering Department, Livermore, CA 94551, USA.
  • 3California National Primate Research Center, University of California, Davis, CA 95616, USA.

Abstract

The emergence of Zika virus (ZIKV) infections in Latin America and Southeast Asia has created an urgent need for new, simple, yet sensitive, diagnostic tests. We highlight recent work using paper-based sensors coupled with CRISPR/Cas9 to detect ZIKV RNA as a new approach to achieve rapid development and deployment of field-ready diagnostics for emerging infectious diseases.

KEYWORDS:

CRISPR/Cas9; emerging infectious diseases; molecular diagnostics; paper microfluidics; toehold sensors

PMID:
27255410
DOI:
10.1016/j.molmed.2016.05.009
[PubMed - in process]
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