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Int J Surg. 2016 Sep;33 Suppl 1:S57-70. doi: 10.1016/j.ijsu.2016.05.050. Epub 2016 May 30.

Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers.

Author information

1
Department of Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy. Electronic address: anubis_m@libero.it.
2
Department of Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy. Electronic address: ruggant@alice.it.
3
Department of Medical and Surgical Sciences, University of Catanzaro, Italy. Electronic address: alessandra.zullo@gmail.com.
4
Department of Emergency, Pugliese-Ciaccio Hospital, Catanzaro, Italy. Electronic address: giuseppegallelli@hotmail.it.
5
Department of Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy. Electronic address: seraf87@gmail.com.
6
Department of Primary Care, Provincial Health Authority of Vibo Valentia, 89900 Vibo Valentia, Italy. Electronic address: m.mazzitelli88@gmail.com.
7
Department of Medical and Surgical Sciences, University of Catanzaro, Italy. Electronic address: agox18@virgilio.it.
8
Department of Medical and Surgical Sciences, University of Catanzaro, Italy. Electronic address: raffaele.eia@alice.it.
9
Department of Medical and Surgical Sciences, University of Catanzaro, Italy. Electronic address: rserra@unicz.it.
10
Department of Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy; Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, Italy. Electronic address: bruno.nardo@unibo.it.

Abstract

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic IRI can seriously impair liver function, even producing irreversible damage, which causes a cascade of multiple organ dysfunction. Many factors, including anaerobic metabolism, mitochondrial damage, oxidative stress and secretion of ROS, intracellular Ca(2+) overload, cytokines and chemokines produced by KCs and neutrophils, and NO, are involved in the regulation of hepatic IRI processes. Matrix Metalloproteinases (MMPs) can be an important mediator of early leukocyte recruitment and target in acute and chronic liver injury associated to ischemia. MMPs and neutrophil gelatinase-associated lipocalin (NGAL) could be used as markers of I-R injury severity stages. This review explores the relationship between factors and inflammatory pathways that characterize hepatic IRI, MMPs and current pharmacological approaches to this disease.

KEYWORDS:

Hepatic ischemia reperfusion injury; Inflammation; Metalloproteinases; Preconditioning

PMID:
27255130
DOI:
10.1016/j.ijsu.2016.05.050
[Indexed for MEDLINE]
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