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J Agric Food Chem. 2016 Jun 22;64(24):4891-9. doi: 10.1021/acs.jafc.6b00805. Epub 2016 Jun 13.

Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake.

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Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
Department of Nutrition, University of California , Davis, California 95616, United States.


Plasma strawberry anthocyanins were characterized in overweight (BMI: 26 ± 2 kg/m(2)) adults (n = 14) on the basis of meal timing. At each visit, subjects ingested three study drinks: two control and one strawberry drink. A strawberry drink was given at either 2 h before the breakfast meal (BM), with the meal (WM), or 2 h after the meal (AM), and control drinks were given at the alternative time points. Plasma anthocyanins and their metabolic conjugates were assessed hourly for 10 h using a triple-quadrupole liquid chromatography mass spectrometer. Maximum concentrations (Cmax), area under the curve (AUC), and bioavailability of pelargonidin-based anthocyanins determined from the main conjugated metabolite (pelargonidin glucuronide) were greater when a strawberry drink was consumed 2 h before the meal (BM) compared to consumption WM or AM (p < 0.05). Our results indicate that the timing of strawberry consumption relative to a meal impacts anthocyanin pharmacokinetic variables.


HPLC; anthocyanins; bioavailability; glucuronide; strawberries

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