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Expert Rev Neurother. 2016 Sep;16(9):1093-110. doi: 10.1080/14737175.2016.1197119. Epub 2016 Jun 30.

Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy.

Author information

1
a Department of Neurology , Ghent University Hospital , Ghent , Belgium.
2
b Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology (LCEN3) , Ghent University , Ghent , Belgium.
3
c Kempenhaeghe, Academic Center for Epileptology , Heeze , the Netherlands.
4
d Department of Electrical Engineering , Eindhoven University of Technology , Eindhoven , the Netherlands.
5
e Department of Psychiatry and Medical Psychology , Ghent University , Ghent , Belgium.
6
f Department of Psychiatry , University Hospital Brussels , Brussels , Belgium.
7
g Department of Electronics and Information Systems, iMinds-IBiTech-MEDISIP , Ghent University , Ghent , Belgium.
8
h Department of Neurology, Maastricht University Medical Center , Maastricht , the Netherlands.

Abstract

INTRODUCTION:

Repetitive transcranial magnetic stimulation (rTMS) is an established non-invasive neurostimulation technique that is able to induce neuromodulatory effects outlasting the duration of the stimulation train. The cortical excitability disturbance in epilepsy provides a rationale for investigating the efficacy of low-frequency rTMS as a treatment for epilepsy patients. Sofar clinical trials in epilepsy patients have shown conflicting results ranging from ineffective to very effective.

AREAS COVERED:

This manuscript provides an overview of the performed studies, retrieved from a PubMed search, and a critical appraisal of their results. A number of conclusions are drawn and potential optimization strategies are discussed. Expert commentary: Although the therapeutic efficacy of rTMS in refractory epilepsy has not yet been established, the non-invasiveness of the technique warrants further investigation of rTMS as a treatment for epilepsy.

KEYWORDS:

Repetitive transcranial magnetic stimulation (rTMS); clinical outcome; epilepsia partialis continua (EPC); epilepsy; status epilepticus (SE); treatment

PMID:
27254399
DOI:
10.1080/14737175.2016.1197119
[Indexed for MEDLINE]

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