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Expert Rev Anti Infect Ther. 2016 Jul;14(7):669-78. doi: 10.1080/14787210.2016.1192462. Epub 2016 Jun 7.

Single dose treatment of malaria - current status and perspectives.

Author information

1
a Centre de Recherches Médicales de Lambaréné , Lambaréné , Gabon.
2
b Institut für Tropenmedizin , Universität Tübingen , Tübingen , Germany.
3
c Department of Medicine I, Division of Infectious Diseases and Tropical Medicine , Medical University of Vienna , Vienna , Austria.

Abstract

INTRODUCTION:

Despite increased international efforts for control and ultimate elimination, malaria remains a major health problem. Currently, artemisinin-based combination therapies are the treatment of choice for uncomplicated malaria exhibiting high efficacy in clinical trial settings in sub-Saharan Africa. However, their administration over a three-day period is associated with important problems of treatment adherence resulting in markedly reduced effectiveness of currently recommended antimalarials under real world settings.

AREAS COVERED:

Antimalarial drug candidates and antimalarial drug combinations currently under advanced clinical development for the indication as single dose antimalarial therapy. Expert commentary: Several new drug candidates and combinations are currently undergoing pivotal proof-of-concept studies or clinical development programmes. The development of a single dose combination therapy would constitute a breakthrough in the control of malaria. Such an innovative treatment approach would simultaneously close the effectiveness gap of current three-day therapies and revolutionize population based interventions in the context of malaria elimination campaigns.

KEYWORDS:

AQ-13; DSM265; KAE609; KAF156; OZ277; OZ439; Single dose treatment; effectiveness; falciparum; ferroquine; malaria; naphthoquine; piperaquine; tafenoquine

PMID:
27254098
DOI:
10.1080/14787210.2016.1192462
[Indexed for MEDLINE]

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