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FEBS Lett. 2016 Jul;590(14):2158-71. doi: 10.1002/1873-3468.12230. Epub 2016 Jun 29.

Identification of putative Z-ring-associated proteins, involved in cell division in human pathogenic bacteria Helicobacter pylori.

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Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.


Cell division in bacteria is initiated by FtsZ, which forms a Z ring at the middle of the cell, between the nucleoids. The Z ring is stabilized by Z ring-associated proteins (Zaps), which crosslink the FtsZ filaments and provide strength. The deletion of Zaps leads to the elongation phenotype with an abnormal Z ring. The components of cell division in Helicobacter pylori are similar to other gram negative bacteria except for the absence of few components including Zaps. Here, we used HHsearch to identify homologs of the missing cell division proteins and got potential hits for ZapA and ZapB, as well as for few other cell division proteins. We further validated the function of the putative ZapA homolog by genetic complementation, immuno-colocalization and biochemical analysis.


FtsA; FtsZ; ZapA; Zaps; cell division

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