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Expert Opin Drug Discov. 2016 Aug;11(8):797-804. doi: 10.1080/17460441.2016.1196183. Epub 2016 Jun 13.

Simple animal models for amyotrophic lateral sclerosis drug discovery.

Author information

1
a INRS-Institut Armand-Frappier , Laval , Canada.
2
b Department of Neuroscience , FRQS Groupe de recherche sur le système nerveux central and CRCHUM, University of Montréal , Montréal , Canada.
3
c Department of Medicine & Physiology , University of Toronto , Toronto , Canada.
4
d Zebrafish Centre for Advanced Drug Discovery , St. Michael's Hospital , Toronto , Canada.

Abstract

INTRODUCTION:

Simple animal models have enabled great progress in uncovering the disease mechanisms of amyotrophic lateral sclerosis (ALS) and are helping in the selection of therapeutic compounds through chemical genetic approaches.

AREAS COVERED:

Within this article, the authors provide a concise overview of simple model organisms, C. elegans, Drosophila and zebrafish, which have been employed to study ALS and discuss their value to ALS drug discovery. In particular, the authors focus on innovative chemical screens that have established simple organisms as important models for ALS drug discovery.

EXPERT OPINION:

There are several advantages of using simple animal model organisms to accelerate drug discovery for ALS. It is the authors' particular belief that the amenability of simple animal models to various genetic manipulations, the availability of a wide range of transgenic strains for labelling motoneurons and other cell types, combined with live imaging and chemical screens should allow for new detailed studies elucidating early pathological processes in ALS and subsequent drug and target discovery.

KEYWORDS:

Amyotrophic lateral sclerosis; C. elegans; Drosophila; chemical genetics; drug discovery; zebrafish

PMID:
27249162
DOI:
10.1080/17460441.2016.1196183
[Indexed for MEDLINE]

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