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Sci Rep. 2016 Jun 1;6:26972. doi: 10.1038/srep26972.

Alteration of the Intra- and Cross- Hemisphere Posterior Default Mode Network in Frontal Lobe Glioma Patients.

Zhang H1, Shi Y2,3, Yao C1, Tang W1, Yao D2,3, Zhang C2,3, Wang M2,3, Wu J1, Song Z2,3.

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Neurosurgery Department, Huashan Hospital, Shanghai Medical College, Fudan University, China.
Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, China.
Shanghai Key Laboratory of Medical Imaging Computing and Computer-Assisted Intervention, 200032 Shanghai, China.


Patients with frontal lobe gliomas often experience neurocognitive dysfunctions before surgery, which affects the default mode network (DMN) to different degrees. This study quantitatively analyzed this effect from the perspective of cerebral hemispheric functional connectivity (FC). We collected resting-state fMRI data from 20 frontal lobe glioma patients before treatment and 20 healthy controls. All of the patients and controls were right-handed. After pre-processing the images, FC maps were built from the seed defined in the left or right posterior cingulate cortex (PCC) to the target regions determined in the left or right temporal-parietal junction (TPJ), respectively. The intra- and cross-group statistical calculations of FC strength were compared. The conclusions were as follows: (1) the intra-hemisphere FC strength values between the PCC and TPJ on the left and right were decreased in patients compared with controls; and (2) the correlation coefficients between the FC pairs in the patients were increased compared with the corresponding controls. When all of the patients were grouped by their tumor's hemispheric location, (3) the FC of the subgroups showed that the dominant hemisphere was vulnerable to glioma, and (4) the FC in the dominant hemisphere showed a significant correlation with WHO grade.

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