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N Engl J Med. 2016 Jun 2;374(22):2175-81. doi: 10.1056/NEJMms1604593.

Assessing the Gold Standard--Lessons from the History of RCTs.

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From the Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (L.E.B.), and the Department of Global Health and Social Medicine, Harvard Medical School (S.H.P., D.S.J.), Boston, and the Department of the History of Science, Harvard University, Cambridge (D.S.J.) - both in Massachusetts; and the Division of General Internal Medicine and the Department of the History of Medicine, Johns Hopkins University School of Medicine, Baltimore (J.A.G.).
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