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J Ophthalmol. 2016;2016:1348347. doi: 10.1155/2016/1348347. Epub 2016 May 8.

Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis.

Author information

1
Clinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, China.
2
Clinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, China; Tianjin Eye Hospital, 4 Gansu Road, Tianjin 300020, China.
3
Clinical College of Ophthalmology, Tianjin Medical University, 4 Gansu Road, Tianjin 300020, China; Tianjin Eye Hospital, 4 Gansu Road, Tianjin 300020, China; Tianjin Key Laboratory of Ophthalmology and Visual Science, 4 Gansu Road, Tianjin 300020, China; Tianjin Eye Institute, 4 Gansu Road, Tianjin 300020, China.

Abstract

PURPOSE:

To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG).

METHODS:

After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included. The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model if I (2) < 50% in the test for heterogeneity; otherwise the random-effects model was used.

RESULTS:

Thirty-one records were obtained, with five being suitable for meta-analysis. The overall results showed that both TT genotype in rs2070744 and GG genotype in rs1799983 are associated with decreased risk of POAG susceptibility. Stratified analysis based on ethnicity showed that the association of rs2070744 with POAG remained only in Caucasians. Results of subgroup analysis by sex indicated association between both polymorphisms and POAG in female group, but not in male group.

CONCLUSIONS:

TT genotype and/or T-allele in rs2070744, as well as GG genotype and/or G-allele in rs1799983, was associated with decreased risk for POAG overall and in female group.

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