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Cryobiology. 2016 Aug;73(1):99-101. doi: 10.1016/j.cryobiol.2016.05.009. Epub 2016 May 27.

Effect of ultra-fast mild hypothermia using total liquid ventilation on hemodynamics and respiratory mechanics.

Author information

1
Department of Pediatrics, Université de Sherbrooke, J1H 5N4, QC, Canada.
2
Department of Mechanical Engineering, Université de Sherbrooke, J1K 2R1, QC, Canada.
3
Inserm, U955, Equipe 3, Créteil, 94000, France; Université Paris Est, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.
4
Department of Pediatrics, Université de Sherbrooke, J1H 5N4, QC, Canada. Electronic address: jean-paul.praud@usherbrooke.ca.
5
Department of Pediatrics, Université de Sherbrooke, J1H 5N4, QC, Canada; Hôpital d'enfant Armand Trousseau, Groupe Hospitalier Universitaire Est Parisien, Université Pierre et Marie Curie, Paris 6, Paris, France.

Abstract

Ultra-fast cooling for mild therapeutic hypothermia (MTH) has several potential applications, including prevention of post-cardiac arrest syndrome. Ultra-fast MTH by total liquid ventilation (TLV) entails the sudden filling of the lungs with a cold perfluorocarbon liquid and its subsequent use to perform TLV. The present physiological study was aimed at assessing whether pulmonary and systemic hemodynamics as well as lung mechanics are significantly altered during this procedure. Pulmonary and systemic arterial pressures, cardiac output as well as airway resistance and respiratory system compliance were measured during ultra-fast MTH by TLV followed by rewarming and normothermia in six healthy juvenile lambs. Results show that none of the studied variables were altered upon varying the perfluorocarbon temperature from 12 to 41 °C. It is concluded that ultra-fast MTH by TLV does not have any deleterious effect on hemodynamics or lung mechanics in healthy juvenile lambs.

KEYWORDS:

Airway resistance; Cardiac output; Pulmonary arterial pressure; Respiratory system compliance; Systemic arterial pressure

PMID:
27242031
DOI:
10.1016/j.cryobiol.2016.05.009
[Indexed for MEDLINE]

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