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Med Clin (Barc). 2016 Aug 5;147(3):95-100. doi: 10.1016/j.medcli.2016.03.031. Epub 2016 May 27.

[Placental atherosclerosis and markers of endothelial dysfunction in infants born to mothers with gestational diabetes].

[Article in Spanish]

Author information

1
Coordinación Auxiliar de Investigación, Instituto Mexicano del Seguro Social, Delegación de Sonora, Obregón, Sonora, México. Electronic address: monica.lopezm26@gmail.com.
2
Dirección de Educación e Investigación, Unidad Médica de Alta Especialidad, Instituto Mexicano del Seguro Social, Obregón, Sonora, México.
3
Centro de Investigación Educativa y Formación Docente, Instituto Mexicano del Seguro Social, Obregón, Sonora, México.
4
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Obregón, Sonora, México.
5
Departamento de Patología, Hospital General Regional 1, Instituto Mexicano del Seguro Social, Obregón, Sonora, México.

Abstract

BACKGROUND AND OBJECTIVE:

The pathophysiology of gestational diabetes itself causes hyperstimulation of adipose tissue and of the placenta cells increasing the production of inflammatory cytokines, which cause changes in the tissues exposed such as the placenta and foetus. Therefore, the objective of this study was to compare metabolic markers and endothelial dysfunction in umbilical cord blood, as well as to determine the presence of atherosclerosis in the placentas of newborn infants of patients with gestational diabetes and in patients with normally progressing pregnancies.

PATIENTS AND METHOD:

An analytical cross-sectional study was carried out in 84 patients, obtaining data such as age, smoking and weight gain in pregnancy; the gestational age of the newborns was determined by Capurro, and their weight and destination subsequent to birth, the placentas were also collected in order to look for atherosclerosis through histological studies and glucose, insulin, VLDL-C, HDL-C, triglycerides, cholesterol, fibrinogen, PCR and markers of endothelial dysfunction (adiponectin, VCAM-1, ICAM-1 and IL-6) were determined in blood samples obtained from the umbilical cord.

RESULTS:

Placental atherosclerosis presented in 28.94% of the group with gestational diabetes compared to 10.52% of the group with normally progressing pregnancies (P=.044); differences were found in glucose, cholesterol, triglycerides, fibrinogen, HOMA-IR, PCR-us, HDL-C, not in VLDL-C. Twenty-one point five percent of the newborns of the gestational diabetes patients required hospitalization, against 5.2% in the control group,

CONCLUSIONS:

Pregnancies that involve diabetes have higher proportion of atherosclerosis, hospitalization of the newborn, insulin resistance, as well as elevation of markers associated with inflammation and endothelial dysfunction in umbilical cord blood.

KEYWORDS:

Aterosclerosis; Atherosclerosis; Diabetes gestacional; Gestational diabetes; Placenta

PMID:
27242015
DOI:
10.1016/j.medcli.2016.03.031
[Indexed for MEDLINE]

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