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Enzymes. 2016;39:255-92. doi: 10.1016/bs.enz.2016.03.006. Epub 2016 May 9.

Animal Mitochondrial DNA Replication.

Author information

1
Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland; Michigan State University, East Lansing, MI, United States.
2
Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista "Júlio de Mesquita Filho", Jaboticabal, SP, Brazil.
3
Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland; Michigan State University, East Lansing, MI, United States. Electronic address: lskaguni@msu.edu.

Abstract

Recent advances in the field of mitochondrial DNA (mtDNA) replication highlight the diversity of both the mechanisms utilized and the structural and functional organization of the proteins at mtDNA replication fork, despite the relative simplicity of the animal mtDNA genome. DNA polymerase γ, mtDNA helicase and mitochondrial single-stranded DNA-binding protein-the key replisome proteins, have evolved distinct structural features and biochemical properties. These appear to be correlated with mtDNA genomic features in different metazoan taxa and with their modes of DNA replication, although substantial integrative research is warranted to establish firmly these links. To date, several modes of mtDNA replication have been described for animals: rolling circle, theta, strand-displacement, and RITOLS/bootlace. Resolution of a continuing controversy relevant to mtDNA replication in mammals/vertebrates will have a direct impact on the mechanistic interpretation of mtDNA-related human diseases. Here we review these subjects, integrating earlier and recent data to provide a perspective on the major challenges for future research.

KEYWORDS:

Animal phylogeny; DNA helicase; DNA polymerase; Mitochondria; Mitochondrial DNA; Replication; Replisome; Single-stranded DNA-binding protein

PMID:
27241933
PMCID:
PMC4964852
DOI:
10.1016/bs.enz.2016.03.006
[Indexed for MEDLINE]
Free PMC Article

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