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Toxicology. 2016 May 16;357-358:11-20. doi: 10.1016/j.tox.2016.05.023. Epub 2016 May 27.

Obesogen effects after perinatal exposure of 4,4'-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice.

Author information

1
Nutrition Physiology and Toxicology Team (NUTox), UMR U866 INSERM, Université de Bourgogne Franche-Comté, AgroSup Dijon, 1 Esplanade Erasme, 21000 Dijon, France.
2
Nutrition Physiology and Toxicology Team (NUTox), UMR U866 INSERM, Université de Bourgogne Franche-Comté, AgroSup Dijon, 1 Esplanade Erasme, 21000 Dijon, France. Electronic address: ludovic.le-corre@u-bourgogne.fr.
3
Plateforme Protéomique-CLIPP, 2 rue Angélique Ducoudray, Bat. Médecine B3, BP37013, 21070 Dijon Cedex, France.
4
UMR 1331 TOXALIM (Research Centre in Food Toxicology), Institut National de la Recherche Agronomique (INRA), 180 chemin de Tournefeuille, 31027 Toulouse, France.
5
UMR 1331 TOXALIM (Research Centre in Food Toxicology), Institut National de la Recherche Agronomique (INRA), Laboratory of Xenobiotic's Cellular and Molecular Toxicology, 400 route des Chappes, BP167, 06903 Sophia-Antipolis Cedex, France.

Abstract

Bisphenol A were removed from consumer products and replaced by chemical substitutes such as Bisphenol S (BPS). Based on their structural similarity, BPS may be obesogen like Bisphenol A in mice. Our objective was to determine the impact of BPS on lipid homeostasis in C57Bl/6 mice after perinatal and chronic exposure. Pregnant mice were exposed to BPS via the drinking water (0.2; 1.5; 50μg/kg bw/d). Treatment began at gestational day 0 and continued in offspring up to 23-weeks old. Then, offspring mice were fed with a standard or high fat diet. The body weight, food consumption, fat mass and energy expenditure were measured. A lipid load test was performed to check the postprandial triglyceridemia. Plasma parameters and mRNA gene expression in adipose tissues were also analysed. BPS induced overweight in male mice offspring fed with a HFD at the two highest doses. There was no change in food intake and energy expenditure. The overweight was correlated to the fat mass, hyperinsulinemia and hyperleptinemia. The plasma triglyceride clearance was significantly increased with BPS and tyloxapol(®) (triglyceride clearance inhibitor) reversed this phenomenon. BPS induced alteration in mRNA expression of marker genes involved in adipose tissue homeostasis: hormone sensitive lipase, PPARγ, insulin receptor, SOCS3 and adiponectin. This is the first time that BPS is described as obesogenic at low doses and after perinatal and chronic exposure in male mice. BPS potentiated the obesity induced by a HFD by inducing the lipid storage linked to faster lipid plasma clearance.

KEYWORDS:

Bisphenol S; Food contaminant; Low dose; Obesogen; Perinatal exposure

PMID:
27241191
DOI:
10.1016/j.tox.2016.05.023
[Indexed for MEDLINE]

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