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Leuk Lymphoma. 2016 Jul;57(7):1517-26. doi: 10.1080/10428194.2016.1185783. Epub 2016 May 31.

Contemporary insights into the pathogenesis and treatment of chronic myeloproliferative neoplasms.

Author information

1
a Tufts University Medical Center , Boston , MA , USA ;
2
b Memorial Sloan Kettering Cancer Center , New York , NY , USA ;
3
c Mayo Clinic Cancer Center , Scottsdale , AZ , USA ;
4
d Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine , RWTH Aachen University , Aachen , Germany ;
5
e Hematology, Universität Heidelberg , Mannheim , Germany ;
6
f Orbassano University Hospital , Turin , Italy ;
7
g Papa Giovani XXIII Hospital and Research Center , Bergamo , Italy ;
8
h Chao Family Comprehensive Cancer Center, University of California Irvine , Irvine , CA , USA.

Abstract

This review is based on the deliberations at the 5th John Goldman Colloquium held in Estoril on 2nd October 2015 and the 9th post-ASH International Workshop on chronic myeloid leukemia (CML) and BCR-ABL1-negative myeloproliferative neoplasms (MPN) which took place on the 10th-11th December 2014, immediately following the 56th American Society of Hematology Annual Meeting. It has been updated since and summarizes the most recent advances in the biology and therapy of these diseases, in particular updates of genetics of MPN, novel insights from mouse MPN models, targeting CML stem cells and its niche; clinical advances include updates on JAK2 inhibitors and other therapeutic approaches to BCR-ABL1-negative MPNs, the use of alpha interferons, updates on tyrosine kinase inhibitors (TKI) randomized trials in CML, TKI cessation studies, and optimal monitoring strategies.

KEYWORDS:

Molecular genetics; myeloid leukemias and dysplasias; stem and primitive progenitor cells

PMID:
27240645
PMCID:
PMC6077976
DOI:
10.1080/10428194.2016.1185783
[Indexed for MEDLINE]
Free PMC Article

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