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Brain Struct Funct. 2017 Mar;222(2):707-716. doi: 10.1007/s00429-016-1240-y. Epub 2016 May 30.

Human ROBO1 regulates white matter structure in corpus callosum.

Author information

1
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
2
Research Programs Unit, Haartman Institute, University of Helsinki, Helsinki, Finland.
3
Folkhälsan Institute of Genetics, Helsinki, Finland.
4
Department of Biosciences and Nutrition, Karolinska Institutet, Hälsovägen 7, 14183, Huddinge, Sweden.
5
Research Programs Unit, Haartman Institute, University of Helsinki, Helsinki, Finland. juha.kere@ki.se.
6
Folkhälsan Institute of Genetics, Helsinki, Finland. juha.kere@ki.se.
7
Department of Biosciences and Nutrition, Karolinska Institutet, Hälsovägen 7, 14183, Huddinge, Sweden. juha.kere@ki.se.
8
Science for Life Laboratory, Karolinska Institutet, Solna, Sweden. juha.kere@ki.se.

Abstract

The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.

KEYWORDS:

Axon guidance receptor homolog 1; Axonal pathfinding; DTI; Roundabout; Single nucleotide polymorphism; Structural MRI

PMID:
27240594
PMCID:
PMC5334444
DOI:
10.1007/s00429-016-1240-y
[Indexed for MEDLINE]
Free PMC Article

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