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Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):445-9. doi: 10.1016/j.aller.2016.03.001. Epub 2016 May 27.

Psychiatric disorders and symptoms severity in pre-school children with cow's milk allergy.

Author information

1
Department of Pediatric Allergy and Immunology, Inonu University Turgut Ozal Medical Center, Malatya, Turkey. Electronic address: erdemtopal44@gmail.com.
2
Department of Pediatric Allergy and Immunology, Inonu University Turgut Ozal Medical Center, Malatya, Turkey.
3
Department of Child and Adolescent Psychiatry, Inonu University Turgut Ozal Medical Center, Malatya, Turkey.
4
Department of Pediatric Allergy and Immunology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.
5
Department of Pediatric Allergy and Immunology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
6
Department of Pediatric Allergy and Immunology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey.

Abstract

BACKGROUND:

Psychiatric disorders are seen frequently in atopic diseases. The present study aims to evaluate the frequency of psychiatric disorders and the severity of psychiatric symptoms in pre-school children with cow's milk allergy.

METHODS:

The parents of the pre-school children with cow's milk allergy were interviewed in person and asked to fill out the Early Childhood Inventory-4 form.

RESULTS:

The cow's milk allergy group included 40 children (27 male, 13 female) with mean age, 44.5±14.7 months, and the control group included 41 children (25 male, 16 female) with mean age, 47.6±15.2 months. It was established that 65% of the group with cow's milk allergy received at least one psychiatric diagnosis, while 36.6% of the control group received at least one psychiatric diagnosis, with a statistically significant difference (p=0.02). Within the psychiatric disorders, attention deficit hyperactivity disorders (odds ratio: 4.9, 95% CI: 1.472-16.856, p=0.006), oppositional defiant disorder (odds ratio: 5.6, 95% CI: 1.139-28.128, p=0.026), and attachment disorder (odds ratio: 4.8, 95% CI: 1.747-13.506, p=0.004) were found significantly higher compared with the healthy control group. When the groups were compared in terms of psychiatric symptom severity scores, calculated by using the Early Childhood Inventory-4 form, attention deficit hyperactivity disorders severity (p=0.006) and oppositional defiant disorder severity (p=0.037) were found to be higher in the cow's milk allergy group.

CONCLUSION:

Psychiatric disorders are frequent and severe in pre-school children with cow's milk allergy.

KEYWORDS:

Attachment disorder; Attention deficit hyperactivity disorder; Cow's milk allergy; ECI-4; Oppositional defiant disorder

PMID:
27240441
DOI:
10.1016/j.aller.2016.03.001
[Indexed for MEDLINE]

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