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Mol Biol (Mosk). 2016 Mar-Apr;50(2):353-9. doi: 10.7868/S0026898416020129.

[Nonstructural protein 1 of tick-borne encephalitis virus activates the expression of immunoproteasome subunits].

[Article in Russian]

Author information

1
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
2
kuzmenko-yulia@mail.ru.

Abstract

The interaction of viral proteins with host cell components plays an important role in antiviral immune response. One of the key steps of antiviral defense is the formation of immunoproteasomes. The effect of nonstructural protein 1 (NS1) of tick-borne encephalitis virus on the immunoproteasome formation was studied. It was shown that cell expression of NS1 does not reduce the efficacy of the immunoproteasome generation in response to interferon-γ stimulation and even increases the content of the immunoproteasome subunits without the interferon-γ treatment. Thus, NS1 of tick-borne encephalitis virus activates, rather than blocks the mechanisms of immune defense in the cell.

KEYWORDS:

immunoproteasome; nonstructural protein 1; tick-borne encephalitis virus

PMID:
27239857
DOI:
10.7868/S0026898416020129
[Indexed for MEDLINE]
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