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Alzheimers Dement (Amst). 2015 Oct 2;1(4):387-94. doi: 10.1016/j.dadm.2015.08.004. eCollection 2015 Dec.

A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings.

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Neuronetrix, Louisville, KY, USA.
Department of Neurology, Nova Southeastern University, Fort Lauderdale, FL, USA.
Department of Psychology, Williams College, Williamstown, MA, USA.
Departments of Psychiatry and Medicine, Duke Medicine and Duke Institute for Brain Sciences, Durham, NC, USA.
Department of Neurology, University of Kentucky, Lexington, KY, USA.
Department of Cognitive & Behavioral Neurology, VA Boston Healthcare System, Boston, MA, USA.
Departments of Psychiatry and Neurology, University of Pennsylvania, Philadelphia, PA, USA.



We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).


A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.


Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test.


Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.


Automated ERP data analysis; Early stage Alzheimer's disease; Event-related potentials; Multicenter clinical trial; Oddball paradigm; Outpatient settings

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