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Alzheimers Dement (Amst). 2015 Apr 23;1(2):136-43. doi: 10.1016/j.dadm.2015.03.001. eCollection 2015 Jun.

A systematic review and meta-analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography.

Author information

1
College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK.
2
Royal Infirmary of Edinburgh, Edinburgh, UK.
3
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK.
4
Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Abstract

INTRODUCTION:

Retinal nerve fiber layer (RNFL) thinning, assessed by optical coherence tomography (OCT), has recently been reported in various dementias.

METHODS:

We conducted a systematic review and meta-analysis to investigate the diagnostic utility of RNFL thickness measurement using OCT in dementia (including Alzheimer's disease [AD] and mild cognitive impairment [MCI]) compared with healthy controls (HC).

RESULTS:

Seventeen studies comparing AD with HC (702 AD eyes and 790 HC eyes) were included, demonstrating a significant reduction in mean RNFL thickness in AD (weighted mean difference [WMD] 12.44, 95% confidence interval or CI [-16.64, -8.25], P <.0001). Five studies comparing MCI and HC (214 MCI eyes and 421 HC eyes) were included demonstrating a significant reduction in mean RNFL thickness in MCI (WMD -8.23, 95% CI [-14.00, -2.45], P =.005). No relevant studies were identified for other dementias.

DISCUSSION:

OCT measurement of RNFL thickness appears diagnostically useful in discriminating between AD, or MCI, and HC.

KEYWORDS:

Alzheimer's disease; Dementia; Mild cognitive impairment; OCT; Optical coherence tomography; Retinal imaging

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