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Neural Plast. 2016;2016:9353929. doi: 10.1155/2016/9353929. Epub 2016 Apr 28.

Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome.

Author information

1
Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.
2
Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China; Heze Municipal Hospital, Heze, Shandong 274000, China.

Abstract

Fragile X syndrome (FXS) is an inheritable neuropsychological disease caused by expansion of the CGG trinucleotide repeat affecting the fmr1 gene on X chromosome, resulting in silence of the fmr1 gene and failed expression of FMRP. Patients with FXS suffer from cognitive impairment, sensory integration deficits, learning disability, anxiety, autistic traits, and so forth. Specifically, the morbidity of anxiety in FXS individuals remains high from childhood to adulthood. By and large, it is common that the change of brain plasticity plays a key role in the progression of disease. But for now, most studies excessively emphasized the one-sided factor on the change of synaptic plasticity participating in the generation of anxiety during the development of FXS. Here we proposed an integrated concept to acquire better recognition about the details of this process.

PMID:
27239350
PMCID:
PMC4864533
DOI:
10.1155/2016/9353929
[Indexed for MEDLINE]
Free PMC Article

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