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Stem Cells Int. 2016;2016:6409546. doi: 10.1155/2016/6409546. Epub 2016 Apr 28.

A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells.

Author information

1
National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China; Center of Digital Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China; 2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.
2
2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.
3
Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
4
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
5
National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China; 2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.

Abstract

Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additional β-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.

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