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Trends Mol Med. 2016 Jul;22(7):530-533. doi: 10.1016/j.molmed.2016.05.001. Epub 2016 May 26.

Sarcomeres and Cardiac Growth: Tension in the Relationship.

Author information

1
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Medicine, Division of Cardiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA 94143, USA. Electronic address: saptarsi.haldar@gladstone.ucsf.edu.
2
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Pediatrics, Division of Cardiology, UCSF School of Medicine, San Francisco, CA 94143, USA. Electronic address: deepak.srivastava@gladstone.ucsf.edu.

Abstract

Genetic mutations in the cardiomyocyte contractile apparatus cause aberrant cardiac growth categorized morphologically as hypertrophic or dilated. A recent study leverages an array of mutant mouse models to extrapolate a new integrated parameter: the myofilament 'tension index', which predicts patterns of cardiac growth resulting from individual sarcomeric mutations. These findings may inform genotype-specific therapies.

PMID:
27237981
DOI:
10.1016/j.molmed.2016.05.001
[Indexed for MEDLINE]

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