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J Neuroimmunol. 2016 Jun 15;295-296:30-40. doi: 10.1016/j.jneuroim.2016.04.007. Epub 2016 Apr 16.

Effect of chronic morphine administration on circulating dendritic cells in SIV-infected rhesus macaques.

Author information

1
Center for Inflammation, Translational and Clinical Lung Research, USA.
2
BioQual Incorporated, 9600 Medical Center Dr., Rockville, MD 20850, USA.
3
Temple University Flow Cytometry Facility, USA.
4
Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.
5
Center for Inflammation, Translational and Clinical Lung Research, USA. Electronic address: rogerst@temple.edu.

Abstract

We studied the effect of chronic morphine administration on the circulating dendritic cell population dynamics associated with SIV infection using rhesus macaques. Animals were either first infected with SIV and then given chronic morphine, or visa versa. SIV infection increased the numbers of myeloid DCs (mDCs), but morphine treatment attenuated this mDC expansion. In contrast, morphine increased the numbers of plasmacytoid DCs (pDCs) in SIV-infected animals. Finally, chronic morphine administration (no SIV) transiently increased the numbers of circulating pDCs. These results show that chronic morphine induces a significant alteration in the available circulating levels of critical antigen-presenting cells.

KEYWORDS:

CD83; Dendritic cells; Morphine; Myeloid; Plasmacytoid; SIV

PMID:
27235346
PMCID:
PMC4884613
DOI:
10.1016/j.jneuroim.2016.04.007
[Indexed for MEDLINE]
Free PMC Article

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