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Clin Perinatol. 2016 Jun;43(2):241-57. doi: 10.1016/j.clp.2016.01.003. Epub 2016 Feb 28.

Bilirubin Binding Capacity in the Preterm Neonate.

Author information

1
Division of Neonatology, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Box 651, 601 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address: Sanjiv_Amin@urmc.rochester.edu.

Abstract

Total serum/plasma bilirubin (TB), the biochemical measure currently used to evaluate and manage hyperbilirubinemia, is not a useful predictor of bilirubin-induced neurotoxicity in premature infants. Altered bilirubin-albumin binding in premature infants limits the usefulness of TB in premature infants. In this article, bilirubin-albumin binding, a modifying factor for bilirubin-induced neurotoxicity, in premature infants is reviewed.

KEYWORDS:

Bilirubin-induced neurotoxicity; Bilirubin:albumin molar ratio; Bilirubin–albumin binding affinity; Total serum bilirubin; Unbound bilirubin

PMID:
27235205
PMCID:
PMC4884605
DOI:
10.1016/j.clp.2016.01.003
[Indexed for MEDLINE]
Free PMC Article

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