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Neurosci Biobehav Rev. 2016 Sep;68:245-255. doi: 10.1016/j.neubiorev.2016.05.028. Epub 2016 May 24.

Self, cortical midline structures and the resting state: Implications for Alzheimer's disease.

Author information

1
Neuroimaging Laboratory, Department of Neurology, University of Campinas (Unicamp), Brazil. Electronic address: weiler_marina@yahoo.com.br.
2
Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.
3
Unit for Neuropsychology and Neurolinguistics, Department of Neurology, University of Campinas (Unicamp), Brazil.
4
Neuroimaging Laboratory, Department of Neurology, University of Campinas (Unicamp), Brazil; Unit for Neuropsychology and Neurolinguistics, Department of Neurology, University of Campinas (Unicamp), Brazil.

Abstract

Different aspects of the self have been reported to be affected in many neurological or psychiatric diseases such as Alzheimer's disease (AD), including mainly higher-level cognitive self-unawareness. This higher sense of self-awareness is most likely related to and dependent on episodic memory, due to the proper integration of ourselves in time, with a permanent conservation of ourselves (i.e., sense of continuity across time). Reviewing studies in this field, our objective is thus to raise possible explanations, especially with the help of neuroimaging studies, for where such self-awareness deficits originate in AD patients. We describe not only episodic (and autobiographical memory) impairment in patients, but also the important role of cortical midline structures, the Default Mode Network, and the resting state (intrinsic brain activity) for the processing of self-related information.

KEYWORDS:

Alzheimer’s disease; Autobiographical memory; Cortical midline structures; Default mode network; Intrinsic activity; Resting state; Self-awareness; Temporal continuity

PMID:
27235083
DOI:
10.1016/j.neubiorev.2016.05.028
[Indexed for MEDLINE]

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