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Diabetes Metab Res Rev. 2017 Jan;33(1). doi: 10.1002/dmrr.2828. Epub 2016 Jun 30.

Benefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes.

Author information

1
Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
2
Department of Food and Nutrition, Umeå University, Umeå, Sweden.
3
Department of Community Medicine and Rehabilitation, Sports Medicine Unit, Umeå University, Umeå, Sweden.
4
Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
5
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
#
Contributed equally

Abstract

BACKGROUND:

Means to reduce future risk for cardiovascular disease in subjects with type 2 diabetes are urgently needed.

METHODS:

Thirty-two patients with type 2 diabetes (age 59 ± 8 years) followed a Paleolithic diet for 12 weeks. Participants were randomized to either standard care exercise recommendations (PD) or 1-h supervised exercise sessions (aerobic exercise and resistance training) three times per week (PD-EX).

RESULTS:

For the within group analyses, fat mass decreased by 5.7 kg (IQR: -6.6, -4.1; p < 0.001) in the PD group and by 6.7 kg (-8.2, -5.3; p < 0.001) in the PD-EX group. Insulin sensitivity (HOMA-IR) improved by 45% in the PD (p < 0.001) and PD-EX (p < 0.001) groups. HbA1c decreased by 0.9% (-1.2, -0.6; p < 0.001) in the PD group and 1.1% (-1.7, -0.7; p < 0.01) in the PD-EX group. Leptin decreased by 62% (p < 0.001) in the PD group and 42% (p < 0.001) in the PD-EX group. Maximum oxygen uptake increased by 0.2 L/min (0.0, 0.3) in the PD-EX group, and remained unchanged in the PD group (p < 0.01 for the difference between intervention groups). Male participants decreased lean mass by 2.6 kg (-3.6, -1.3) in the PD group and by 1.2 kg (-1.3, 1.0) in the PD-EX group (p < 0.05 for the difference between intervention groups).

CONCLUSIONS:

A Paleolithic diet improves fat mass and metabolic balance including insulin sensitivity, glycemic control, and leptin in subjects with type 2 diabetes. Supervised exercise training may not enhance the effects on these outcomes, but preserves lean mass in men and increases cardiovascular fitness. Copyright © 2016 John Wiley & Sons, Ltd.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01513798.

KEYWORDS:

Paleolithic diet; diet intervention; exercise; glycosylated haemoglobin A; insulin sensitivity; leptin; type 2 diabetes

PMID:
27235022
PMCID:
PMC5402870
DOI:
10.1002/dmrr.2828
[Indexed for MEDLINE]
Free PMC Article

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