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J Infect Dis. 2016 Sep 1;214(5):707-11. doi: 10.1093/infdis/jiw226. Epub 2016 May 27.

Nucleoside Inhibitors of Zika Virus.

Author information

1
Department of Virology, Veterinary Research Institute, Brno.
2
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague.
3
Department of Virology, Veterinary Research Institute, Brno Institute of Parasitology, Biology Center of the Czech Academy of Sciences Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
4
National Institute of Health Dr Ricardo Jorge-CEVDI/INSA, Águas de Moura, Portugal.
5
Aix Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health, EPV UMR_D 190 Emergence des Pathologies Virales, France.
6
Rega Institute for Medical Research, KU Leuven, Belgium.

Abstract

There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2'-C- or 2'-O-methyl-substituted nucleosides, 2'-C-fluoro-2'-C-methyl-substituted nucleosides, 3'-O-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2'-C-methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.

KEYWORDS:

Zika virus; antiviral; flavivirus; nucleoside analogue; therapy

PMID:
27234417
DOI:
10.1093/infdis/jiw226
[Indexed for MEDLINE]

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