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Gen Thorac Cardiovasc Surg. 2016 Aug;64(8):470-5. doi: 10.1007/s11748-016-0662-z. Epub 2016 May 27.

Multicenter prospective study of sublobar resection for c-stage I non-small cell lung cancer patients unable to undergo lobectomy (KLSG-0801): complete republication.

Author information

1
General Thoracic Surgery, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.
2
Division of General Thoracic Surgery, Hoshigaoka Medical Center, Japan Community Healthcare Organization (JCHO), Hirakata, Osaka, 578-5811, Japan. nsawabata@hotmail.com.
3
Division of Health Care, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. nsawabata@hotmail.com.
4
Division of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
5
General Thoracic Surgery, Keio University, Shinjyuku, Tokyo, Japan.
6
General Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Bunkyou, Tokyo, Japan.
7
General Thoracic Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
8
General Thoracic Surgery, Saitama Medical University Saitama Medical Center, Kawagoe, Saitama, Japan.
9
General Thoracic Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
10
General Thoracic Surgery, Dokkyo Medical University, Tokyo, Japan.

Abstract

BACKGROUND:

Local therapy for stage I non-small cell lung cancer (NSCLC) is divided into surgical and radiation treatment, and given to patients unable to tolerate a lobectomy. A prospective phase II study of cases that received stereotactic body radio therapy (SBRT) (JCOG0403) revealed an overall 3-year survival rate (3-YSR) of 76.0 %, 3-year relapse free survival rate (3-YRFS) of 69.0 %, and rate of morbidity of grade 3 or greater of 9 %. However, few prospective multicenter studies have reported regarding surgery for high-risk stage I NSCLC patients.

METHODS:

We investigated this issue in the setting of a prospective multicenter observational study. Thirty-two high-risk NSCLC patients (30 males, 2 females; median age 74 years, 61-85 years) were analyzed.

RESULTS:

Two (6.3 %) showed morbidity of grade 3 or greater, though there were no postoperative deaths. The margin local control rate was 97.0 % (surgical margin recurrence, 1) and local recurrence control rate was 75.0 % (ipsilateral thorax recurrence, 8), while the 3-YSR and 3-YRFS was 79.0 and 75.9 %, respectively.

CONCLUSION:

A sublobar pulmonary resection for patients unable to tolerate a lobectomy with stage I NSCLC was shown to be safe and provided results comparable with those of SBRT.

KEYWORDS:

Conservative limited pulmonary resection; Non-small cell lung cancer; Prospective study; Stage I

PMID:
27234224
DOI:
10.1007/s11748-016-0662-z
[Indexed for MEDLINE]

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