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Fertil Steril. 2016 Jul;106(1):6-15. doi: 10.1016/j.fertnstert.2016.05.003. Epub 2016 May 24.

Criteria, prevalence, and phenotypes of polycystic ovary syndrome.

Author information

1
Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia; Medical Company IDK, Samara, Russian Federation; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation. Electronic address: dlizneva@gru.edu.
2
Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation.
3
Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia.
4
Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia; Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia.

Abstract

Polycystic ovary syndrome (PCOS) is a highly prevalent disorder effecting reproductive-aged women worldwide. This article addresses the evolution of the criteria used to diagnosis PCOS; reviews recent advances in the phenotypic approach, specifically in the context of the extended Rotterdam criteria; discusses limitations of the current criteria used to diagnosis, particularly when studying adolescents and women in the peri- and postmenopause; and describes significant strides made in understanding the epidemiology of PCOS. This review recognizes that although there is a high prevalence of PCOS, there is increased variability when using Rotterdam 2003 criteria, owing to limitations in population sampling and approaches used to define PCOS phenotypes. Last, we discuss the distribution of PCOS phenotypes, their morbidity, and the role that referral bias plays in the epidemiology of this syndrome.

KEYWORDS:

Phenotypes; polycystic ovary syndrome; prevalence; referral bias

[Indexed for MEDLINE]

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