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Inflamm Res. 2016 Sep;65(9):717-24. doi: 10.1007/s00011-016-0953-y. Epub 2016 May 27.

Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women.

Author information

1
Department of Obstetrics and Gynecology, Maternal and Children's Hospital of Shenzhen City, Southern Medical University, Shenzhen, 518000, China.
2
Department of Cell Biology and Medical Genetics, Shenzhen University Health Science Center, Shenzhen, 518000, China.
3
Department of Obstetrics and Gynecology, Maternal and Children's Hospital of Shenzhen City, Southern Medical University, Shenzhen, 518000, China. szwangchenhong@vip.163.com.

Abstract

OBJECTIVES:

To investigate the association of polymorphisms in genes involved in coagulation, fibrinolysis, and inflammation with pre-eclampsia (PE) in a Chinese population.

METHODS:

It is a case-control study of patients with PE (n = 117) and controls (n = 286) from the Maternal and Children's Hospital of Shenzhen City carried out between June 2014 and May 2015. The rs6025, rs6020, rs1801133, rs1799963, rs1799889, rs231775, rs1800896, rs1800629, and rs1799724 polymorphisms were analyzed using Snap Shot. Multifactor dimensionality reduction (MDR) and logistic regression analyses were carried out to assess the interactions among these SNPs.

RESULTS:

The frequencies of polymorphisms in tumor necrosis factor-α (TNF-α) (rs1800629 and rs1799724) and interleukin 10 (IL-10) (rs1800896) were significantly different between patients with PE and controls (P < 0.05). The best interaction model identified a marginally significant interaction between rs1799724 and rs1800896 (P = 0.05).

CONCLUSIONS:

This study suggests that polymorphisms in the TNF-α and IL-10 genes could be associated with PE, but additional studies are necessary to explore the mechanisms involving these polymorphisms and the gene-gene interactions involved in the susceptibility to PE.

KEYWORDS:

Interleukin 10; Multifactor dimensionality reduction; Polymorphism; Pre-eclampsia; Tumor necrosis factor-alpha

PMID:
27233255
DOI:
10.1007/s00011-016-0953-y
[Indexed for MEDLINE]

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