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Curr Opin Cell Biol. 2016 Aug;41:109-16. doi: 10.1016/j.ceb.2016.05.004. Epub 2016 May 25.

Permeability barriers for generating a unique ciliary protein and lipid composition.

Author information

1
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: kjverhey@umich.edu.
2
Department of Biology, Temple University, Philadelphia, PA 19122, USA.

Abstract

Cilia (and flagella) are microtubule-based protrusions that are found in single or multiple copies on the surface of most eukaryotic cells. Defects in cilia formation and/or function have now been correlated with an expanding spectrum of human genetic diseases termed ciliopathies. Recent work indicates that cilia are indeed a bona fide organelle with a unique protein and lipid content that enables specific cellular functions. Despite the physiological and clinical relevance of cilia, our understanding of how a unique protein and lipid composition is generated for this organelle remains poor. Here we review recent work on the mechanisms that determine the protein and lipid content, and thus the functional outputs, of this unique organelle.

PMID:
27232950
PMCID:
PMC4983468
DOI:
10.1016/j.ceb.2016.05.004
[Indexed for MEDLINE]
Free PMC Article
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