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Nat Rev Immunol. 2016 May 27;16(6):341-52. doi: 10.1038/nri.2016.42.

Gut microbiota, metabolites and host immunity.

Author information

1
Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
2
Harvard Medical School, Boston, Massachusetts 02115, USA.
3
Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
4
Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

Abstract

The microbiota - the collection of microorganisms that live within and on all mammals - provides crucial signals for the development and function of the immune system. Increased availability of technologies that profile microbial communities is facilitating the entry of many immunologists into the evolving field of host-microbiota studies. The microbial communities, their metabolites and components are not only necessary for immune homeostasis, they also influence the susceptibility of the host to many immune-mediated diseases and disorders. In this Review, we discuss technological and computational approaches for investigating the microbiome, as well as recent advances in our understanding of host immunity and microbial mutualism with a focus on specific microbial metabolites, bacterial components and the immune system.

PMID:
27231050
PMCID:
PMC5541232
DOI:
10.1038/nri.2016.42
[Indexed for MEDLINE]
Free PMC Article

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