Format

Send to

Choose Destination
Neurodegener Dis Manag. 2016 Jun;6(3):223-36. doi: 10.2217/nmt-2016-0007. Epub 2016 May 27.

Brain stimulation in Huntington's disease.

Author information

1
Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.
2
Institute of Clinical Neuroscience & Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany.
3
Department of Neurosurgery, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany.

Abstract

Huntington's disease (HD) is a hereditary neurodegenerative disorder which is associated with severe disturbances of motor function, especially choreatic movements, cognitive decline and psychiatric symptoms. Various brain stimulation methods have been used to study brain function in patients with HD. Moreover, brain stimulation has evolved as an alternative or additive treatment option, besides current symptomatic medical treatment. This article summarizes the results of brain stimulation to better understand the characteristics of cortical excitability and plasticity in HD and gives a perspective on the therapeutic role for noninvasive and invasive neuromodulatory brain stimulation methods.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02535884.

KEYWORDS:

Huntington's disease; deep brain stimulation; transcranial brain stimulation

PMID:
27230813
DOI:
10.2217/nmt-2016-0007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center